Frequently Asked Questions about UCERIS
Find answers below to commonly asked questions about UCERIS and ulcerative colitis (UC).
What is UCERIS?
UCERIS is a different kind of steroid for active, mild to moderate ulcerative colitis (UC). UCERIS decreases inflammation throughout the colon and is for people experiencing a flare-up who are trying to reach remission, a period of time without symptoms.
What makes UCERIS different?
UCERIS is a different kind of steroid for active, mild to moderate ulcerative colitis (UC). It decreases inflammation throughout the colon with a delivery designed to target medicine throughout the full length of the colon, where the disease is located.
Because of the way UCERIS is absorbed and processed in the body, most of it does not stay in the bloodstream, and therefore it has a safety profile similar to placebo (sugar pill). UCERIS decreases the severity of inflammation in the colon and helps to heal the lining of the colon, thereby helping to eliminate UC symptoms.
Who should take UCERIS?
UCERIS is approved for people experiencing active, mild to moderate symptoms of ulcerative colitis. Those who have had an allergic reaction to UCERIS or any of its ingredients should not take it.
How does UCERIS work?
UCERIS works by decreasing the level of inflammation, redness, and swelling in the colon. By decreasing inflammation, redness, and swelling, the symptoms of ulcerative colitis are brought under control.
UCERIS travels through the digestive system and stays intact until it reaches the colon. After reaching its destination and dissolving, the medicine forms a type of gel that slowly coats the entire colon.
What are the side effects of UCERIS?
UCERIS demonstrated a safety profile similar to placebo (sugar pill). For the five most common steroid-related side effects (mood changes, sleep changes, insomnia, acne, rounding of the face), the occurrence rates were similar in both the UCERIS and sugar pill groups.
Safety profile similar to placebo
Adverse Events Experienced by ≥2% of Patients in 2 Clinical Trials
UCERIS 9 mg (n=255)
|Headache||29 (11.4)||27 (10.5)|
|Nausea||13 (5.1)||11 (4.3)|
|Decreased blood cortisol||11 (4.3)||1 (0.4)|
|Upper abdominal pain (stomach-area pain)||10 (3.9)||5 (1.9)|
|Fatigue (tiredness)||8 (3.1)||5 (1.9)|
|Flatulence||6 (2.4)||5 (1.9)|
|Abdominal distention (bloating)||6 (2.4)||2 (0.8)|
|Acne||6 (2.4)||5 (1.9)|
|Urinary tract infection||5 (2.0)||1 (0.4)|
|Arthralgia (joint pain)||5 (2.0)||4 (1.6)|
|Constipation||5 (2.0)||2 (0.8)|
Steroid-related Side Effects
For a complete list of side effects, see the full Prescribing Information. Be sure to tell your doctor about any side effects that bother you or don't go away.
How do I take UCERIS?
- Take UCERIS exactly as your doctor tells you.
- Take UCERIS in the morning.
- Take UCERIS tablets whole. Do not chew or crush UCERIS before swallowing.
What is the recommended dose for UCERIS?
The recommended dose for UCERIS is one 9-mg tablet to be taken once daily in the morning.
What should I tell my doctor before taking UCERIS?
Before you take UCERIS, tell your doctor if you:
- have liver problems
- are planning to have surgery
- have chickenpox or measles or have recently been near anyone with chickenpox or measles
- have an infection
- have or had a family history of diabetes, cataracts or glaucoma
- have or had tuberculosis
- have high blood pressure (hypertension)
- have decreased bone mineral density (osteoporosis)
- have stomach ulcers
- have any other medical condition
- are pregnant or plan to become pregnant. It is not known if UCERIS may harm your unborn baby.
- are breastfeeding or plan to breastfeed. UCERIS can pass into breast milk and may harm your baby. You and your doctor should decide if you will take UCERIS or breastfeed. You should not do both.
Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. UCERIS and other medicines may affect each other causing side effects.
Especially tell your doctor if you take:
- a steroid medicine
- medicines that suppress your immune system (immunosuppressants)
- ketoconazole or other medicines that affect how your liver works.
Ask your doctor or pharmacist if you are not sure if your medicine is one listed above.
How much does UCERIS cost?
UCERIS is a low-cost option to treat ulcerative colitis. Most eligible patients with commercial insurance pay only $25 for each UCERIS prescription. Learn more
What is ulcerative colitis?
Ulcerative colitis (UC) is a disease that causes inflammation, or areas of redness and swelling, in a part of the large intestine called the colon. Inflammation in the colon can lead to bleeding, production of pus, diarrhea, and abdominal or stomach discomfort. About 700,000 Americans have UC, and it typically first affects people between the ages of 15 and 30. The disease appears equally in men and women.
UC is chronic, meaning it is an ongoing condition with no known cure. It's a type of inflammatory bowel disease (IBD). One can easily confuse IBD with irritable bowel syndrome (IBS), but they are very different. IBS is not inflammatory in nature and only affects the muscle contractions of the colon.
What is a flare-up in ulcerative colitis?
Ulcerative colitis symptoms typically come and go. When symptoms appear, a person is experiencing what is commonly referred to as a "flare-up."
What is remission in ulcerative colitis?
A person with ulcerative colitis may experience months or even years without any symptoms. Any span of time without any symptoms is called "remission."